Opportunity Information: Apply for RFA PS 23 006
This CDC cooperative agreement (RFA PS 23 006; CFDA 93.084) focuses on a persistent barrier to HIV prevention and care for Hispanic/Latino gay, bisexual, and other men who have sex with men (HLMSM): medical mistrust. The opportunity is built around the idea that mistrust can prevent or delay people from getting key HIV services, which in turn contributes to ongoing HIV disparities. The CDC is seeking community-driven work that does not just document that mistrust exists, but digs into why it develops in this population, how it operates across different contexts, and what can realistically be done to reduce it in ways that improve access to prevention and care.
The grant is designed as a two-phase study. In Phase 1, recipients conduct formative research to identify the historical and structural drivers of medical mistrust among HLMSM. This phase emphasizes understanding pathways that lead to mistrust, including how experiences with healthcare systems, policies, discrimination, stigma, immigration-related concerns, language barriers, and other systemic factors may shape perceptions of safety and fairness in medical settings. Phase 1 also calls for identifying existing interventions and approaches that have been used to build trust and improve engagement with HIV prevention and care services. The intent is not to reinvent solutions blindly, but to learn what has worked (or shows promise), for whom, and under what conditions.
In Phase 2, recipients move from understanding to action by evaluating the implementation of targeted, multilevel interventions intended to build trust in healthcare and HIV prevention services. "Multilevel" signals that the CDC is not looking only for individual-level education or outreach, but for strategies that can operate across multiple layers such as providers and clinics, community organizations, service delivery systems, and broader structural conditions that influence how HLMSM experience care. The emphasis on implementation evaluation suggests the program is interested in how interventions are put into practice in real-world settings, what barriers and facilitators affect uptake, and whether these interventions measurably improve engagement with prevention and care (for example, more timely use of HIV testing, PrEP access, linkage to care, retention, or other prevention-related outcomes), while also strengthening trust.
The CDC intends to fund three US jurisdictions, with preference for areas that are prioritized under the Ending the HIV Epidemic (EHE) Initiative (Priority Jurisdictions Phase I). A key selection consideration is having a large Hispanic/Latino population (specified as 30 percent or more based on 2020 US Census data) so the work can meaningfully examine variation across Hispanic/Latino subgroups. The opportunity explicitly notes interest in capturing differences among groups such as Mexicans, Central Americans, Puerto Ricans, and differences by nativity (US-born vs non-US-born). That focus reflects an understanding that "Hispanic/Latino" is not a single uniform community, and that drivers of mistrust and effective trust-building strategies may differ by cultural background, migration history, language, and local context.
Eligible applicants are broad and include state, county, and city governments; special districts; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities; nonprofits (with or without 501(c)(3) status); for-profit organizations (including small businesses). The award ceiling is $500,000, with three expected awards. Applications were due February 23, 2023 (11:59 pm ET). As a cooperative agreement, the structure generally implies substantial CDC involvement beyond standard grant oversight, typically through collaboration on project design, implementation planning, and evaluation expectations.
Overall, the opportunity is meant to generate practical, community-informed evidence about what drives medical mistrust among HLMSM and how to address it through implementable interventions. The results are intended to support federal HIV prevention goals, especially EHE and the National HIV/AIDS Strategy, by tackling a specific upstream driver of disparities that can keep people from benefiting from proven HIV prevention and care services.Apply for RFA PS 23 006
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Identifying and Addressing Historical and Structural Drivers of Medical Mistrust among Hispanic/Latino Gay, Bisexual and Other Men Who Have Sex with Men (HLMSM) for HIV Prevention" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.084.
- This funding opportunity was created on Dec 22, 2022.
- Applicants must submit their applications by Feb 23, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses.
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Frequently Asked Questions (FAQs)
What is this CDC funding opportunity?
This opportunity is a CDC cooperative agreement focused on reducing medical mistrust as a barrier to HIV prevention and care for Hispanic/Latino gay, bisexual, and other men who have sex with men (HLMSM). It is identified as RFA PS 23 006 with CFDA 93.084.
What problem is the grant trying to address?
The grant targets medical mistrust as a persistent barrier that can prevent or delay HLMSM from using key HIV services. The CDC frames mistrust as an upstream driver that contributes to ongoing HIV disparities by limiting access to prevention and care.
Who is the priority population for this project?
The primary focus is Hispanic/Latino gay, bisexual, and other men who have sex with men (HLMSM). The opportunity also emphasizes examining variation across Hispanic/Latino subgroups rather than treating the population as a single uniform community.
Why does the opportunity focus on medical mistrust (instead of only awareness or education)?
The CDC is seeking work that goes beyond documenting that mistrust exists. The intent is to understand why mistrust develops, how it functions in different contexts, and what can realistically reduce it in ways that improve engagement with HIV prevention and care services.
What kind of study design does the CDC expect?
The opportunity is designed as a two-phase study: Phase 1 centers on formative research to understand drivers and pathways of medical mistrust, and Phase 2 evaluates implementation of targeted, multilevel interventions intended to build trust and improve engagement with HIV prevention and care.
What happens in Phase 1?
In Phase 1, recipients conduct formative research to identify historical and structural drivers of medical mistrust among HLMSM. This includes examining pathways that lead to mistrust and identifying existing interventions or approaches that have been used to build trust and improve engagement with HIV prevention and care services.
What kinds of drivers of medical mistrust are included in Phase 1?
The opportunity highlights drivers such as experiences with healthcare systems and policies, discrimination, stigma, immigration-related concerns, language barriers, and other systemic factors that may shape perceptions of safety and fairness in medical settings.
Does Phase 1 require identifying existing interventions?
Yes. Phase 1 calls for identifying existing interventions and approaches that have been used to build trust and improve engagement. The CDC signals that the goal is to learn what has worked (or shows promise), for whom, and under what conditions, rather than reinventing solutions without evidence.
What happens in Phase 2?
In Phase 2, recipients evaluate the implementation of targeted, multilevel interventions intended to build trust in healthcare and HIV prevention services, with attention to how interventions perform in real-world settings and whether they improve engagement in prevention and care.
What does "multilevel interventions" mean in this opportunity?
"Multilevel" indicates the CDC is not looking only for individual-level education or outreach. Strategies may operate across multiple layers such as providers and clinics, community organizations, service delivery systems, and broader structural conditions that influence how HLMSM experience care.
What does the CDC mean by "implementation evaluation" in Phase 2?
The emphasis is on how interventions are put into practice in real-world settings, what barriers and facilitators affect uptake, and whether the interventions measurably improve engagement with HIV prevention and care while strengthening trust.
What outcomes or engagement measures are mentioned as examples?
The opportunity lists examples such as more timely HIV testing, improved PrEP access, linkage to care, retention, and other prevention-related outcomes, along with improvements in trust.
How many awards does the CDC expect to make?
The CDC expects to make three awards.
What is the maximum award amount?
The award ceiling is $500,000.
Where does the CDC intend to fund projects?
The CDC intends to fund three U.S. jurisdictions, with preference for areas prioritized under the Ending the HIV Epidemic (EHE) Initiative (Priority Jurisdictions Phase I).
Is there a population requirement related to Hispanic/Latino residents?
Yes. A key selection consideration is having a large Hispanic/Latino population, specified as 30% or more based on 2020 U.S. Census data, to support meaningful examination of variation across Hispanic/Latino subgroups.
Does the opportunity expect applicants to address differences among Hispanic/Latino subgroups?
Yes. The opportunity explicitly notes interest in capturing differences among groups such as Mexicans, Central Americans, and Puerto Ricans, and differences by nativity (U.S.-born vs non-U.S.-born).
Who is eligible to apply?
Eligible applicants include state, county, and city governments; special districts; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities; nonprofits (with or without 501(c)(3) status); and for-profit organizations (including small businesses).
What kind of award mechanism is this?
This is a cooperative agreement. The description notes that cooperative agreements generally imply substantial CDC involvement beyond standard grant oversight, typically including collaboration on project design, implementation planning, and evaluation expectations.
What is the application deadline listed for this opportunity?
Applications were due February 23, 2023 at 11:59 pm ET.
How does this opportunity connect to federal HIV goals?
The opportunity is intended to generate practical, community-informed evidence about what drives medical mistrust among HLMSM and how to address it through implementable interventions. The results are meant to support federal HIV prevention goals, especially the Ending the HIV Epidemic (EHE) initiative and the National HIV/AIDS Strategy, by addressing an upstream driver of disparities.
Is the CDC looking for purely descriptive research?
No. The opportunity emphasizes that it is not enough to document mistrust; recipients are expected to examine why it develops and how it operates, and then evaluate the implementation of interventions aimed at reducing mistrust and improving engagement with HIV prevention and care.
Does the opportunity indicate what types of settings might be involved?
Yes. The multilevel framing points to potential activity across providers and clinics, community organizations, service delivery systems, and structural conditions that shape experiences of care.
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| Re-envisioning Excellence and Accessibility in Clinic-based HIV Services (“REACH 95”) Activity Apply for 72012123RFA00001 Funding Number: 72012123RFA00001 Agency: Agency for International Development, Ukraine USAID-Kiev Category: Health Funding Amount: $19,000,000 |
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| Strengthening Scale Up of HIV Prevention, Care and Treatment Programs in South Sudan under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 23 0034 Funding Number: CDC RFA GH 23 0034 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
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| Comprehensive Systems Integration for Adolescent and Young Adult Health Apply for HRSA 23 079 Funding Number: HRSA 23 079 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $1,514,450 |
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| Strengthening Laboratory Systems that Support Diagnosis, Treatment, Prevention, and Management of HIV/AIDS and Related Public Health Diseases in the Republic of South Sudan under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 23 0035 Funding Number: CDC RFA GH 23 0035 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Exploring Preferences for Long-Acting Antiretroviral Therapies (LA-ART) in a Community-Based Sample of Priority Populations Living with HIV Who are Disproportionately Affected Apply for RFA PS 23 003 Funding Number: RFA PS 23 003 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $333,000 |
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