Opportunity Information: Apply for RFA PS 23 006
This CDC cooperative agreement (RFA PS 23 006; CFDA 93.084) focuses on a persistent barrier to HIV prevention and care for Hispanic/Latino gay, bisexual, and other men who have sex with men (HLMSM): medical mistrust. The opportunity is built around the idea that mistrust can prevent or delay people from getting key HIV services, which in turn contributes to ongoing HIV disparities. The CDC is seeking community-driven work that does not just document that mistrust exists, but digs into why it develops in this population, how it operates across different contexts, and what can realistically be done to reduce it in ways that improve access to prevention and care.
The grant is designed as a two-phase study. In Phase 1, recipients conduct formative research to identify the historical and structural drivers of medical mistrust among HLMSM. This phase emphasizes understanding pathways that lead to mistrust, including how experiences with healthcare systems, policies, discrimination, stigma, immigration-related concerns, language barriers, and other systemic factors may shape perceptions of safety and fairness in medical settings. Phase 1 also calls for identifying existing interventions and approaches that have been used to build trust and improve engagement with HIV prevention and care services. The intent is not to reinvent solutions blindly, but to learn what has worked (or shows promise), for whom, and under what conditions.
In Phase 2, recipients move from understanding to action by evaluating the implementation of targeted, multilevel interventions intended to build trust in healthcare and HIV prevention services. "Multilevel" signals that the CDC is not looking only for individual-level education or outreach, but for strategies that can operate across multiple layers such as providers and clinics, community organizations, service delivery systems, and broader structural conditions that influence how HLMSM experience care. The emphasis on implementation evaluation suggests the program is interested in how interventions are put into practice in real-world settings, what barriers and facilitators affect uptake, and whether these interventions measurably improve engagement with prevention and care (for example, more timely use of HIV testing, PrEP access, linkage to care, retention, or other prevention-related outcomes), while also strengthening trust.
The CDC intends to fund three US jurisdictions, with preference for areas that are prioritized under the Ending the HIV Epidemic (EHE) Initiative (Priority Jurisdictions Phase I). A key selection consideration is having a large Hispanic/Latino population (specified as 30 percent or more based on 2020 US Census data) so the work can meaningfully examine variation across Hispanic/Latino subgroups. The opportunity explicitly notes interest in capturing differences among groups such as Mexicans, Central Americans, Puerto Ricans, and differences by nativity (US-born vs non-US-born). That focus reflects an understanding that "Hispanic/Latino" is not a single uniform community, and that drivers of mistrust and effective trust-building strategies may differ by cultural background, migration history, language, and local context.
Eligible applicants are broad and include state, county, and city governments; special districts; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities; nonprofits (with or without 501(c)(3) status); for-profit organizations (including small businesses). The award ceiling is $500,000, with three expected awards. Applications were due February 23, 2023 (11:59 pm ET). As a cooperative agreement, the structure generally implies substantial CDC involvement beyond standard grant oversight, typically through collaboration on project design, implementation planning, and evaluation expectations.
Overall, the opportunity is meant to generate practical, community-informed evidence about what drives medical mistrust among HLMSM and how to address it through implementable interventions. The results are intended to support federal HIV prevention goals, especially EHE and the National HIV/AIDS Strategy, by tackling a specific upstream driver of disparities that can keep people from benefiting from proven HIV prevention and care services.Apply for RFA PS 23 006
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Identifying and Addressing Historical and Structural Drivers of Medical Mistrust among Hispanic/Latino Gay, Bisexual and Other Men Who Have Sex with Men (HLMSM) for HIV Prevention" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.084.
- This funding opportunity was created on Dec 22, 2022.
- Applicants must submit their applications by Feb 23, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses.
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| Long-Acting Injectables for the Treatment of HIV in Non-Clinic Community-Based Settings Apply for RFA PS 23 004 Funding Number: RFA PS 23 004 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $1,000,000 |
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| Provision of Voluntary Medical Male Circumcision (VMMC) for HIV Prevention in the Republic of South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 23 0006 Funding Number: CDC RFA GH 23 0006 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Medication-Assisted Treatment – Prescription Drug and Opioid Addiction Apply for TI 23 001 Funding Number: TI 23 001 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $750,000 |
| A Strategic Approach to Advancing Health Equity for Priority Populations with or at Risk for Diabetes Apply for CDC RFA DP 23 0020 Funding Number: CDC RFA DP 23 0020 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $3,300,000 |
| Re-envisioning Excellence and Accessibility in Clinic-based HIV Services (“REACH 95”) Activity Apply for 72012123RFA00001 Funding Number: 72012123RFA00001 Agency: Agency for International Development, Ukraine USAID-Kiev Category: Health Funding Amount: $19,000,000 |
| National Asian Language Tobacco Quitline Apply for CDC RFA DP 23 0011 Funding Number: CDC RFA DP 23 0011 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $900,000 |
| Enhancing Telehealth Strategies to Support Retention and Adherence to Antiretroviral Therapy (ART) Apply for RFA PS 23 002 Funding Number: RFA PS 23 002 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $450,000 |
| Strengthening Scale Up of HIV Prevention, Care and Treatment Programs in South Sudan under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 23 0034 Funding Number: CDC RFA GH 23 0034 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Rape Prevention and Education: Assessing Coalition Capacity to Advance Primary Prevention Apply for CDC RFA CE 23 0006 Funding Number: CDC RFA CE 23 0006 Agency: Department of Health and Human Services, Centers for Disease Control - NCIPC Category: Health Funding Amount: $115,641 |
| Comprehensive Systems Integration for Adolescent and Young Adult Health Apply for HRSA 23 079 Funding Number: HRSA 23 079 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $1,514,450 |
| Pediatric Emergency Care Applied Research Network (PECARN) Apply for HRSA 23 073 Funding Number: HRSA 23 073 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $700,000 |
| Scaling-up Sustainable Voluntary Medical Male Circumcision (VMMC) through Improvements in the Availability, Integration, and Quality of HIV Prevention Services in Zimbabwe under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 23 0017 Funding Number: CDC RFA GH 23 0017 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Sustainable, Innovative, and Agile Community and Facility HIV Prevention, Care and Treatment Services for Epidemic Control among all Populations in Zimbabwe under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 23 0018 Funding Number: CDC RFA GH 23 0018 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Strengthening an Integrated Comprehensive Approach for HIV Services for Adolescents and Young People through Determined, Resilient, AIDS-Free Mentored and Safe (DREAMS) Program in Zimbabwe under the President's Emergency Plan for AIDS Relief (PE Apply for CDC RFA GH 23 0019 Funding Number: CDC RFA GH 23 0019 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Strengthening Laboratory Systems that Support Diagnosis, Treatment, Prevention, and Management of HIV/AIDS and Related Public Health Diseases in the Republic of South Sudan under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 23 0035 Funding Number: CDC RFA GH 23 0035 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Exploring Preferences for Long-Acting Antiretroviral Therapies (LA-ART) in a Community-Based Sample of Priority Populations Living with HIV Who are Disproportionately Affected Apply for RFA PS 23 003 Funding Number: RFA PS 23 003 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $333,000 |
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