Opportunity Information: Apply for RFA NS 19 038
The NINDS Human Cell and Data Repository (NHCDR) funding opportunity (RFA-NS-19-038) is a National Institutes of Health (NIH) cooperative agreement intended to support a centralized, high-quality repository of human cell resources and associated data for the neuroscience research community. Issued by the Department of Health and Human Services through NIH's National Institute of Neurological Disorders and Stroke (NINDS), this announcement is a reissue of an earlier solicitation (RFA-NS-15-009) and is focused on enabling broad access to well-characterized human cell lines that can accelerate basic and translational research on neurological disorders. The mechanism is a U24 cooperative agreement, which generally means the awardee will work closely with NIH program staff on goals, milestones, and oversight, rather than operating with complete independence. Clinical trials are explicitly not allowed under this FOA.
The core purpose of the NHCDR is to sustain and grow a collection of human fibroblast lines and induced pluripotent stem cell (iPSC) lines, while also improving the utility of those resources over time. The funded repository is expected to maintain the existing collection, and also to develop, characterize, and expand new source cells and iPSCs aligned with the NINDS mission. In practical terms, this points to a program that does more than simply store vials in freezers. It implies active curation and continuous improvement of the collection, including quality control, identity verification, characterization of cell lines, and creation of standardized documentation so that researchers can trust what they are receiving and compare results across labs.
Another major component is the generation of new high-quality iPSC lines, including genetic modification "where appropriate." That language typically signals that the repository should have the capability, expertise, and governance to create or support engineered cell lines when it meaningfully advances neurological disease research. Examples might include introducing or correcting disease-associated variants, creating isogenic controls, or generating reporter lines, as long as these activities fit within ethical, regulatory, and scientific best practices and remain within the non-clinical scope of the award.
A central expectation is broad distribution. The NHCDR is meant to serve qualified researchers across academia and industry, which means the repository must function as a national-scale service platform with reliable fulfillment, clear access policies, and a user-oriented approach. This includes making cell resources available widely, likely with standardized material transfer processes, consistent shipping and handling practices, and accompanying data that helps investigators interpret what they receive. Because the title explicitly includes "Cell and Data Repository," the award also implies stewardship of the associated datasets that make the biospecimens useful, such as provenance, donor and phenotype descriptors as allowed, reprogramming and culture details, genetic/quality metrics, and other relevant characterization outputs.
In terms of funding structure and scale, the opportunity is categorized as discretionary and uses a cooperative agreement funding instrument. The award ceiling listed is $850,000, and the announcement anticipates a single award, meaning NINDS intended to fund one central repository awardee rather than multiple regional centers. With one expected award, applicants would generally need to demonstrate the ability to operate at national capacity, including infrastructure, staffing, quality management, distribution logistics, and data management practices that can support a large and diverse user base.
Eligibility is broad and includes many types of domestic organizations: various levels of government entities, public and private institutions of higher education, nonprofit organizations with and without 501(c)(3) status, for-profit organizations (including small businesses and other than small businesses), tribal governments and tribal organizations, and other eligible applicants as described in the full FOA text. That breadth suggests NINDS was primarily concerned with operational capability and scientific/technical fit rather than restricting the applicant pool by organizational type.
Key administrative details in the source data include the creation date (Aug 30, 2019) and an original closing date (Oct 22, 2019). The CFDA number associated with the program is 93.853, which corresponds to NINDS funding. Overall, the opportunity is best understood as support for a national resource: a curated, quality-controlled, actively developed bank of fibroblast and iPSC lines, paired with robust data and distribution systems, designed to lower barriers for researchers and speed progress toward understanding mechanisms of neurological disease and developing translational research tools.Apply for RFA NS 19 038
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "The NINDS Human Cell and Data Repository (U24 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853.
- This funding opportunity was created on Aug 30, 2019.
- Applicants must submit their applications by Oct 22, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $850,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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