Opportunity Information: Apply for HRSA 21 096
The Quality Improvement Solutions for Sustained Epidemic Control Project (QISSEC) is a U.S. government funding opportunity from the Department of Health and Human Services, Health Resources and Services Administration (HRSA), designed to strengthen the quality of HIV services in countries supported by the U.S. President's Emergency Plan for AIDS Relief (PEPFAR). The central idea behind the project is that achieving and maintaining HIV epidemic control is not only about expanding access to services, but also about making sure those services are consistently high quality where care actually happens: at the site level, meaning the facilities and locations where people diagnosed with HIV receive ongoing treatment and support, and within the surrounding community systems that influence whether patients can stay in care.
QISSEC focuses on improving the full HIV care continuum, with an emphasis on practical, on-the-ground changes that make services more effective and reliable over time. In plain terms, the project aims to help facilities and local health systems deliver HIV care that is more effective and efficient, more patient-centered, safer, easier to access, and more equitable. These quality aims are especially directed toward low- and middle-income countries (LMICs) that receive PEPFAR support, and toward the vulnerable and key populations that PEPFAR identifies as needing more targeted approaches because they often face the greatest barriers to consistent, respectful, and clinically appropriate care.
A major driver behind the opportunity is PEPFAR's FY21 priority that quality health services must be built into routine practice, not treated as a one-time improvement campaign. PEPFAR requires country programs to include explicit quality management (QM) practices, which combine quality assurance (QA) and quality improvement (QI). QA generally refers to making sure minimum standards are met and that services follow established requirements, while QI is about continuously testing, measuring, and refining changes to improve performance and outcomes. QISSEC is positioned as a way to help countries and implementing partners move beyond ad hoc improvements and instead build sustained capability to manage and improve quality as part of everyday service delivery and partner oversight.
The funding will support two cooperative agreements, meaning awardees will not simply receive funds and operate independently, but will work in a more collaborative relationship with HRSA, with substantial federal involvement typical of cooperative agreements. Through these awards, HRSA is looking for recipients who can facilitate evidence-informed interventions that can be scaled up and spread across sites and settings, rather than remaining isolated pilot efforts. In practice, this means identifying proven or promising approaches, adapting them appropriately, and developing the operational know-how needed so that country programs can replicate successful changes at more facilities and maintain them as conditions evolve.
QISSEC places strong emphasis on long-term change management and sustainability. Applicants are expected to help build country capacity to use QI methodologies, tools, and techniques; improve how QI and QA work is documented; and continuously strengthen staff knowledge and skills so that improvements persist even when external technical assistance decreases. The project is meant to help sites systematically identify gaps in service delivery, understand why those gaps exist, and implement interventions that are culturally and medically appropriate, feasible in resource-constrained environments, and durable over time. The goal is not only better processes, but also better health outcomes, contributing directly to sustained epidemic control.
The opportunity sits within the broader context of PEPFAR's evolution over nearly two decades into a large, complex, and high-impact global program with mature partners and stakeholders. HRSA frames QISSEC as part of a renewed commitment to PEPFAR, specifically aimed at filling persistent gaps and tackling remaining barriers that keep some countries or populations from achieving or maintaining epidemic control. The Notice of Funding Opportunity (NOFO) explicitly aligns with the PEPFAR 2021 Country Operational Plan (COP21) Guidance, which reinforces that quality management must be integrated into both service delivery and the way partners are managed and held accountable.
Key administrative details from the notice include the funding opportunity number HRSA-21-096, the activity area being health (CFDA 93.266), and the fact that the award ceiling is listed as 0 in the posted data (often indicating that a fixed ceiling is not specified in that field, rather than implying no funding). The opportunity category is discretionary, and eligibility is listed broadly as "Others," with further clarification referenced in the full eligibility section of the notice. The opportunity was created March 8, 2021, with an original closing date of May 7, 2021, and it anticipates making two awards.Apply for HRSA 21 096
- The Department of Health and Human Services, Health Resources and Services Administration in the health sector is offering a public funding opportunity titled "Quality Improvement Solutions for Sustained Epidemic Control Project (QISSEC)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.266.
- This funding opportunity was created on Mar 08, 2021.
- Applicants must submit their applications by May 07, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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