Opportunity Information: Apply for PAR 24 211
The NHLBI Career Transition Award for Intramural Postdoctoral Fellows and Research Trainees (K22, Clinical Trial Required) is a National Institutes of Health grant opportunity designed to help outstanding postdoctoral fellows and research trainees currently working within the NHLBI Division of Intramural Research move into independent, tenure-track (or equivalent) research careers at extramural institutions. The core idea is to provide a structured runway from mentored training inside NHLBI to launching an independent research program outside NIH, with dedicated funding that follows the investigator through that transition if key milestones are met.
The award is organized into two connected phases totaling up to five years of support. The first phase is a mentored intramural period of up to two years, carried out within NHLBI intramural laboratories. During this time, the awardee is expected to build a strong foundation for independence by advancing a defined research program, producing clear evidence of progress (such as publications, preliminary data, and scientific milestones), and preparing to compete for and secure an independent position. The second phase is an extramural period of three years, conducted at an eligible U.S.-based institution, where the awardee continues and expands the research program as an independent investigator. Because this specific K22 is labeled "Clinical Trial Required," the supported research is expected to include a clinical trial component consistent with NIH definitions and requirements, meaning applicants should be prepared for the added expectations around trial design, oversight, and reporting.
A critical feature of this program is that the move from the intramural phase to the extramural phase is not automatic. NHLBI makes a transition decision based on a formal progress review that examines the success of the candidate's work during the mentored intramural period and evaluates the proposed research plan to be implemented at the extramural institution. In practical terms, the awardee must demonstrate strong scientific productivity and readiness for independence, and must present a credible, well-supported plan for the next stage of research once they relocate. Only after NHLBI approves this transition does the extramural funding phase begin.
In terms of who can apply and where the award can be hosted, the opportunity lists a wide range of eligible applicant organizations for the extramural phase, including public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and multiple levels of government entities (state, county, city/township, special districts), among others. It also explicitly highlights additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions, along with faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. At the same time, the announcement is clear that non-U.S. entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components are not allowed under NIH policy, meaning the extramural phase must be anchored in the United States without foreign components as defined by NIH.
Administratively, this is a discretionary grant opportunity run by the National Institutes of Health, with the NHLBI as the sponsoring institute, and it falls under the health funding activity category. The opportunity number is PAR 24-211, and it is associated with CFDA numbers 93.233 and 93.837 through 93.840, reflecting NHLBI and NIH assistance listings tied to heart, lung, blood, sleep, and related research areas. The listing shows an original closing date of July 12, 2027. While an award ceiling is not specified in the provided source text, the defining structure is the two-year intramural mentored phase plus the three-year extramural independent phase, with continuation contingent on NHLBI approval after progress review.
Overall, this K22 mechanism is meant for a very specific pipeline: intramural NHLBI postdoctoral researchers who are ready to step into independence but benefit from a funded, milestone-based bridge to an external faculty-level or equivalent role. The program emphasizes both demonstrated progress during the NHLBI mentored period and a strong, executable research plan for the extramural setting, with the added expectation that the research will involve a clinical trial consistent with NIH requirements.Apply for PAR 24 211
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NHLBI Career Transition Award for Intramural Postdoctoral Fellows and Research Trainees (K22 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840.
- This funding opportunity was created on 2024-07-15.
- Applicants must submit their applications by 2027-07-12.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NHLBI Career Transition Award for Intramural Postdoctoral Fellows and Research Trainees (K22, Clinical Trial Required) - PAR-24-211
What is this grant opportunity?
This opportunity is the NHLBI Career Transition Award for Intramural Postdoctoral Fellows and Research Trainees (K22, Clinical Trial Required). It is a National Institutes of Health (NIH) discretionary grant designed to help outstanding postdoctoral fellows and research trainees in the NHLBI Division of Intramural Research transition into independent, tenure-track (or equivalent) research careers at eligible extramural U.S. institutions.
What is the main purpose of the NHLBI K22 Career Transition Award?
The core purpose is to provide a structured, milestone-based runway from mentored training inside NHLBI intramural laboratories to launching an independent research program at an extramural institution, with funding that can continue through the transition if specific progress and readiness expectations are met.
Who is this K22 intended for?
It is intended for outstanding postdoctoral fellows and research trainees who are currently working within the NHLBI Division of Intramural Research and who are preparing to move into an independent research position at an extramural institution.
How is the award structured?
The award includes two connected phases totaling up to five years of support: (1) a mentored intramural phase of up to two years within NHLBI intramural laboratories, and (2) an extramural phase of three years at an eligible U.S.-based institution where the awardee continues the research program as an independent investigator.
How long is the intramural (mentored) phase?
The intramural mentored period can last up to two years and is conducted within NHLBI intramural laboratories.
What is expected during the intramural phase?
During the mentored intramural phase, the awardee is expected to build a strong foundation for independence by advancing a defined research program, generating clear evidence of progress (for example, publications, preliminary data, and scientific milestones), and preparing to compete for and secure an independent position.
How long is the extramural (independent) phase?
The extramural phase lasts three years and is conducted at an eligible U.S.-based institution.
What is expected during the extramural phase?
During the extramural phase, the awardee is expected to continue and expand the research program as an independent investigator at the host extramural institution.
Is the transition from the intramural phase to the extramural phase automatic?
No. Transition is not automatic. NHLBI makes a transition decision based on a formal progress review of the candidate's intramural accomplishments and an evaluation of the proposed extramural research plan.
What does NHLBI review to approve the transition to the extramural phase?
NHLBI reviews the success of the candidate's work during the mentored intramural period (including scientific productivity and evidence of readiness for independence) and evaluates the proposed research plan to be implemented at the extramural institution. The extramural phase begins only after NHLBI approves the transition.
What does "Clinical Trial Required" mean for this K22?
Because this funding opportunity is labeled "Clinical Trial Required," the supported research is expected to include a clinical trial component consistent with NIH definitions and requirements. Applicants should be prepared for the added expectations tied to clinical trial design, oversight, and reporting.
Where does the intramural phase take place?
The intramural phase takes place within NHLBI intramural laboratories, as part of the NHLBI Division of Intramural Research.
Where can the extramural phase be hosted?
The extramural phase must be hosted at an eligible U.S.-based institution. The opportunity lists a broad range of eligible applicant organization types for the extramural phase, spanning higher education, nonprofit, for-profit, small business, and various government entities, among others.
What types of organizations are eligible to host/apply for the extramural phase?
Eligible applicant organizations include public and private institutions of higher education; nonprofits (with or without 501(c)(3) status); for-profit organizations (other than small businesses); small businesses; and multiple levels of government entities such as state, county, city/township, and special district governments, among others.
Are minority-serving and community-based institutions included in eligible organization types?
Yes. The opportunity explicitly highlights additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions. It also notes faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
Are non-U.S. organizations eligible to apply or host the extramural phase?
No. The announcement states that non-U.S. entities are not eligible to apply.
Can a U.S. organization include a non-U.S. component for the extramural phase?
No. The announcement states that non-U.S. components of U.S. organizations are not eligible, and that foreign components are not allowed under NIH policy. The extramural phase must be anchored in the United States without foreign components as defined by NIH.
Which agency and institute sponsor this opportunity?
This is an NIH discretionary grant opportunity sponsored by the National Institutes of Health, with the National Heart, Lung, and Blood Institute (NHLBI) as the sponsoring institute.
What is the opportunity number?
The opportunity number is PAR 24-211.
What funding activity category does this opportunity fall under?
It falls under the health funding activity category.
What CFDA/Assistance Listing numbers are associated with this opportunity?
The listing references CFDA/Assistance Listing numbers 93.233 and 93.837 through 93.840, reflecting NHLBI/NIH assistance listings tied to heart, lung, blood, sleep, and related research areas.
What is the closing date shown in the provided information?
The provided information shows an original closing date of July 12, 2027.
Is there an award ceiling specified?
No award ceiling is specified in the provided information. The defining structure described is up to two years of intramural mentored support followed by three years of extramural independent support, contingent on NHLBI transition approval after progress review.
What makes this K22 different from a typical single-phase award?
This K22 is specifically designed as a bridge from NHLBI intramural training to extramural independence. It is explicitly milestone-based, includes a formal transition review by NHLBI, and is structured to support the investigator through a relocation to a U.S.-based extramural institution if readiness and the proposed next-stage research plan are approved.
What kind of career outcome is this award meant to support?
The award is meant to support the move into an independent, tenure-track (or equivalent) research career at an extramural institution, with the investigator launching and growing an independent research program outside NIH.
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