Opportunity Information: Apply for RFA MH 22 105
The National Institutes of Health (NIH) funding opportunity titled "Expanding Differentiated Care Approaches for Adolescents Living with HIV (R01 Clinical Trial Optional)" (Funding Opportunity Number RFA-MH-22-105; CFDA 93.242) supports research to improve HIV care outcomes for adolescents, a population that consistently experiences some of the weakest results along the HIV care continuum globally. The core problem the opportunity is trying to address is that many HIV service models have been built around adult patients and conventional clinic-based delivery, while adolescents often face different barriers, needs, and life circumstances that can make standard care hard to access, hard to stay engaged with, or simply not a good fit.
The opportunity centers on "differentiated care" (also called differentiated service delivery), meaning client-centered approaches that simplify and adapt HIV services across prevention-to-treatment-to-long-term management in ways that better match what adolescents need while also reducing unnecessary workload and congestion in health systems. In practice, this can involve changing where, when, how, and by whom services are delivered, with the goal of maintaining or improving clinical outcomes (like viral suppression and retention in care) while making services more adolescent-friendly and more efficient for clinics and providers. The emphasis is not limited to one point in the continuum; it encourages thinking broadly about adaptations across care, rather than assuming a one-size-fits-all clinic schedule or service package.
A major motivation for the announcement is that most existing differentiated care evidence has historically focused on antiretroviral therapy (ART) delivery for stable adults, particularly in high HIV prevalence settings in sub-Saharan Africa. While the broader differentiated care field has grown and the literature increasingly supports these approaches for people living with HIV, programs and studies still too rarely focus on adolescents living with HIV (ALWH) or directly address their unique needs. This funding opportunity is intended to stimulate research that closes that gap by developing, testing, and expanding differentiated care models designed specifically with adolescents in mind, rather than simply adapting adult models without sufficient evidence that they work for younger people.
The mechanism is an R01 grant, and clinical trials are optional, meaning applicants may propose clinical trial research if it fits their aims, but they are not required to do so. The opportunity is categorized as discretionary grant funding within the health activity area. The original closing date listed for the opportunity was January 6, 2022, and the posting indicates a creation date of October 18, 2021; the award ceiling and expected number of awards are not specified in the provided source information.
Eligibility is broad and includes many types of U.S.-based and international organizations. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations (other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses) and small businesses; and other entities. The announcement also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, non-domestic (non-U.S.) entities (foreign organizations), regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions. Overall, the funding opportunity is designed to bring in a wide range of researchers and implementers capable of testing adolescent-focused differentiated HIV care approaches in varied settings and health systems.Apply for RFA MH 22 105
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Expanding Differentiated Care Approaches for Adolescents Living with HIV (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242.
- This funding opportunity was created on 2021-10-18.
- Applicants must submit their applications by 2022-01-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Expanding Differentiated Care Approaches for Adolescents Living with HIV (R01 Clinical Trial Optional)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-MH-22-105.
What CFDA number is associated with this opportunity?
The CFDA number listed is 93.242.
What is the main goal of this funding opportunity?
The goal is to support research that improves HIV care outcomes for adolescents living with HIV by developing, testing, and expanding differentiated (client-centered) care approaches that better fit adolescents' needs and circumstances.
Why is NIH emphasizing adolescents living with HIV in this opportunity?
Adolescents consistently experience some of the weakest outcomes along the HIV care continuum globally. Many common HIV service models were designed around adult patients and conventional clinic-based delivery, which may not match adolescents' barriers, needs, and life circumstances.
What problem is this opportunity trying to address?
The opportunity is trying to address the mismatch between traditional adult-focused, clinic-centered HIV service models and the realities adolescents face, which can make standard care hard to access, hard to stay engaged with, or simply not a good fit.
What does "differentiated care" mean in the context of this announcement?
Differentiated care (also called differentiated service delivery) refers to client-centered approaches that simplify and adapt HIV services across prevention, treatment, and long-term management. These adaptations are intended to better match what adolescents need while reducing unnecessary workload and congestion in health systems.
What kinds of changes can differentiated care include?
The announcement describes changes in where, when, how, and by whom HIV services are delivered, with the intent of maintaining or improving clinical outcomes (such as viral suppression and retention in care) while making services more adolescent-friendly and more efficient for clinics and providers.
Is the focus only on antiretroviral therapy (ART) delivery?
No. While much of the historical evidence on differentiated care has focused on ART delivery for stable adults, this opportunity encourages applicants to think broadly about adaptations across the HIV care continuum rather than assuming a one-size-fits-all clinic schedule or service package.
Why does NIH note a gap in the existing evidence base?
NIH notes that most differentiated care evidence has historically focused on stable adults, particularly in high HIV prevalence settings in sub-Saharan Africa. Programs and studies still too rarely focus on adolescents living with HIV or directly address their unique needs, and this opportunity is intended to stimulate research that closes that gap.
What funding mechanism is being used?
This opportunity uses the NIH R01 grant mechanism.
Are clinical trials required?
No. Clinical trials are optional. Applicants may propose clinical trial research if it fits their aims, but they are not required to include a clinical trial.
What type of funding is this categorized as?
It is categorized as discretionary grant funding within the health activity area.
What was the original closing date listed for this opportunity?
The original closing date listed was January 6, 2022.
When was this opportunity posted/created?
The posting indicates a creation date of October 18, 2021.
Is the award ceiling provided in the source information?
No. The award ceiling is not specified in the provided information.
Is the expected number of awards provided in the source information?
No. The expected number of awards is not specified in the provided information.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based and international organizations, including various government entities, higher education institutions, tribal governments and organizations, nonprofits (with and without 501(c)(3) status), for-profit organizations (including small businesses), and other entities.
Are U.S. government entities eligible (state, local, and special districts)?
Yes. Eligible applicants include state governments; county, city, or township governments; and special district governments.
Are public and private universities eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are independent school districts eligible?
Yes. Independent school districts are listed as eligible applicants.
Are Native American tribal governments eligible?
Yes. Federally recognized Native American tribal governments are eligible. The announcement also highlights Indian/Native American tribal governments other than federally recognized as an additional eligible category.
Are Native American tribal organizations eligible?
Yes. Native American tribal organizations (other than federally recognized tribal governments) are included as eligible applicants.
Are nonprofits eligible even if they do not have 501(c)(3) status?
Yes. Nonprofits with and without 501(c)(3) status (other than institutions of higher education) are listed as eligible.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are eligible, and small businesses are also listed as eligible.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly highlighted among the additional eligible applicant categories.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. Non-domestic (non-U.S.) entities (foreign organizations) are explicitly listed as eligible.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included among the highlighted eligible applicant categories.
Does the opportunity encourage a range of settings and health systems?
Yes. The opportunity is described as designed to bring in a wide range of researchers and implementers capable of testing adolescent-focused differentiated HIV care approaches in varied settings and health systems.
What kinds of outcomes is the opportunity trying to improve?
The announcement emphasizes improving HIV care outcomes for adolescents and references clinical outcomes such as viral suppression and retention in care.
Does the opportunity imply that adolescent models should be developed specifically for adolescents rather than borrowed from adult care?
Yes. A central motivation is to develop, test, and expand models designed specifically with adolescents in mind, rather than simply adapting adult models without sufficient evidence that they work for younger people.
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