Opportunity Information: Apply for PA 18 390
The grant opportunity "Epidemiology and Prevention in Alcohol Research (R01 - Clinical Trial Optional)" (Funding Opportunity Number PA 18-390) is a National Institutes of Health (NIH) discretionary funding announcement that supports investigator-initiated research projects focused on alcohol use and its public health impacts. It uses the R01 research project grant mechanism, which is the NIH's standard award type for funding mature, hypothesis-driven research programs. The "clinical trial optional" designation means applicants may propose studies that include clinical trials, but a clinical trial is not required; strong applications can range from observational epidemiology to prevention research, with or without intervention testing, depending on the scientific aims.
At its core, the FOA is aimed at advancing knowledge about the epidemiology of alcohol use, alcohol-related harms, and alcohol use disorders, as well as improving prevention strategies for underage drinking and related consequences. That includes research that maps patterns and trends in alcohol consumption across populations, identifies risk and protective factors, clarifies pathways leading from alcohol exposure to health and social harms, and examines how alcohol-related outcomes vary by age, sex, geography, race and ethnicity, socioeconomic status, and other determinants. On the prevention side, the opportunity is intended to foster studies that develop, refine, and evaluate approaches to prevent underage drinking, reduce alcohol-related harms, and prevent alcohol use disorders, including multi-level strategies that may operate at the individual, family, school, healthcare system, community, or policy level.
Because this is an investigator-initiated FOA, it is designed to be broad and flexible in terms of research topics and methods, as long as the work is clearly tied to alcohol epidemiology and/or prevention. Competitive projects often leverage rigorous designs and strong analytic approaches, such as population-based surveys, cohort studies, case-control studies, natural experiments, mixed-methods research, implementation and dissemination approaches, or intervention studies when appropriate. The intent is not only to describe the burden of alcohol use and harms, but to generate actionable evidence that can inform prevention programs, public health practice, and policy decisions.
Eligibility is intentionally expansive. In addition to common applicant types such as state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (other than small businesses); and small businesses, the FOA explicitly welcomes applications from a wide range of mission-driven and community-connected entities. These include Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), federally recognized Native American tribal governments, tribal organizations and tribal governments that are not federally recognized, faith-based or community-based organizations, eligible federal agencies, regional organizations, and applicants located in U.S. territories or possessions. The FOA also permits non-domestic (non-U.S.) entities (foreign organizations) to apply, reflecting NIH's interest in scientifically strong research that can address alcohol-related public health questions with global relevance or comparative value.
Administratively, this is a grant (not a contract) within the NIH health research portfolio and is associated with CFDA number 93.273. The FOA was created on 2017-11-27, and the provided record lists an original closing date of 2020-05-07 (noting that NIH announcements sometimes have multiple receipt dates over time or may be reissued; applicants typically verify the current status and active due dates in the official NIH listing). No award ceiling or expected number of awards is specified in the provided source data, which is common for many NIH FOAs because final award amounts and counts depend on the quality of applications, available appropriations, and program priorities.
Overall, the opportunity is best read as NIH inviting well-justified, methodologically strong R01 proposals that either (1) deepen understanding of who is affected by alcohol use and alcohol-related harms and why, or (2) produce evidence about what prevents underage drinking, reduces harms, and lowers the incidence or severity of alcohol use disorders. The broad eligibility language and "clinical trial optional" framing are meant to encourage a wide range of institutions and investigators, including community-based and minority-serving organizations, to contribute research that is both scientifically rigorous and relevant to real-world prevention needs.Apply for PA 18 390
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Epidemiology and Prevention in Alcohol Research (R01 - Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
- This funding opportunity was created on 2017-11-27.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Epidemiology and Prevention in Alcohol Research (R01 - Clinical Trial Optional)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA 18-390.
Who is the funder for this opportunity?
This is a National Institutes of Health (NIH) discretionary funding announcement within the NIH health research portfolio.
What type of funding is this (grant or contract)?
This opportunity is a grant, not a contract.
What grant mechanism does this opportunity use?
It uses the R01 research project grant mechanism, NIH's standard award type for supporting mature, hypothesis-driven research programs.
What does "Clinical Trial Optional" mean for this FOA?
"Clinical trial optional" means applicants may propose studies that include a clinical trial, but a clinical trial is not required. Applications can range from observational epidemiology to prevention research, with or without intervention testing, depending on the scientific aims.
What is the overall focus of the research supported by this FOA?
The FOA supports investigator-initiated research focused on alcohol use and its public health impacts, specifically advancing knowledge in alcohol epidemiology and prevention (including underage drinking and related consequences).
What kinds of epidemiology topics are relevant to this opportunity?
Relevant epidemiology topics include research that maps patterns and trends in alcohol consumption, identifies risk and protective factors, clarifies pathways from alcohol exposure to health and social harms, and examines how alcohol-related outcomes vary across different population characteristics.
Does this FOA support research on alcohol-related harms and alcohol use disorders?
Yes. The FOA is aimed at advancing knowledge about the epidemiology of alcohol-related harms and alcohol use disorders, including who is affected and why.
Does this FOA support prevention research related to underage drinking?
Yes. A core intent is to improve prevention strategies for underage drinking and related consequences, including approaches that prevent underage drinking, reduce harms, and prevent alcohol use disorders.
What types of prevention strategies can be studied?
The FOA supports studies that develop, refine, and evaluate prevention approaches, including multi-level strategies operating at the individual, family, school, healthcare system, community, or policy level.
Is the FOA narrow or broad in the research topics it allows?
It is designed to be broad and flexible because it is an investigator-initiated FOA, as long as the work is clearly tied to alcohol epidemiology and/or prevention.
What study designs and methods are described as competitive for this FOA?
Competitive projects often use rigorous designs and strong analytic approaches, such as population-based surveys, cohort studies, case-control studies, natural experiments, mixed-methods research, implementation and dissemination approaches, or intervention studies when appropriate.
Does the FOA emphasize practical or actionable outcomes?
Yes. The intent goes beyond describing burden; it aims to generate actionable evidence that can inform prevention programs, public health practice, and policy decisions.
Who is eligible to apply?
Eligibility is described as expansive. Eligible applicants include (among others) state/county/city/township governments, special district governments, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses.
Are minority-serving institutions explicitly encouraged or included?
Yes. The FOA explicitly welcomes applications from Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are tribal governments and tribal organizations eligible?
Yes. The FOA includes federally recognized Native American tribal governments, tribal organizations, and tribal governments that are not federally recognized.
Are faith-based or community-based organizations eligible to apply?
Yes. The FOA explicitly includes faith-based or community-based organizations among eligible applicant types.
Are applicants in U.S. territories or possessions eligible?
Yes. The FOA includes applicants located in U.S. territories or possessions.
Can non-U.S. (foreign) organizations apply?
Yes. The FOA permits non-domestic (non-U.S.) entities (foreign organizations) to apply.
Is this opportunity limited to U.S.-only public health questions?
No. By allowing foreign organizations to apply, the FOA reflects interest in strong research that can address alcohol-related public health questions with global relevance or comparative value.
Does the provided information include an award ceiling?
No. The provided source data states that no award ceiling is specified, which is common for NIH FOAs where award amounts depend on application quality, appropriations, and program priorities.
Does the provided information list the expected number of awards?
No. The provided source data indicates that an expected number of awards is not specified.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA 93.273.
When was this FOA created?
The FOA was created on 2017-11-27.
What closing date is listed in the provided record?
The provided record lists an original closing date of 2020-05-07.
Should applicants verify whether the FOA is still active and what the current due dates are?
Yes. The information notes that NIH announcements may have multiple receipt dates over time or may be reissued, so applicants typically verify the current status and active due dates in the official NIH listing.
What makes an application a strong fit for this FOA, based on the description provided?
Strong proposals are described as well-justified and methodologically strong R01 projects that either (1) deepen understanding of who is affected by alcohol use and harms and why, or (2) produce evidence about what prevents underage drinking, reduces harms, and lowers the incidence or severity of alcohol use disorders.
Does the FOA encourage participation from community-connected organizations?
Yes. The broad eligibility language and the "clinical trial optional" framing are intended to encourage a wide range of institutions and investigators, including community-based organizations, to contribute research that is rigorous and relevant to real-world prevention needs.
What population differences are explicitly mentioned as areas to examine?
The FOA mentions examining how alcohol-related outcomes vary by age, sex, geography, race and ethnicity, socioeconomic status, and other determinants.
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