Opportunity Information: Apply for HT9425 23 TBDRP TDRA
The DoD Tick-Borne Disease Research Program (TBDRP) Therapeutic/Diagnostic Research Award (FY23) is a competitive Department of Defense funding opportunity designed to push forward practical, hypothesis-driven research that can lead to better treatments and better diagnostic tools for Lyme disease and other tick-borne diseases. The program is aimed at work with clear translational promise, meaning the research should be positioned to move beyond basic discovery and toward real-world clinical impact. A central priority is improving patient care and quality of life for military Service Members, Veterans, their families and beneficiaries, and also the broader U.S. public affected by tick-borne illnesses and related conditions.
This award supports two main tracks of work. Under the Treatment Focus Area, projects are expected to be therapeutic evaluation studies that help generate and test new ideas for drug or treatment discovery, particularly at early or preclinical stages. In other words, the program is looking for solid, data-driven studies that evaluate promising therapeutic concepts before they are ready for large clinical trials, with the intent of building the evidence base needed to move candidates forward. Under the Diagnosis Focus Area, proposals should center on diagnostic approaches that can be readily integrated into clinical settings. That emphasis signals that the DoD wants diagnostics that are not only scientifically interesting, but also realistic for routine use in healthcare environments, with attention to factors like usability, workflow fit, and the practical steps needed for adoption.
Across both focus areas, the solicitation makes it clear that projects should be empirical and product-driven. That typically implies measurable development milestones, tangible outputs (such as a candidate therapeutic strategy, assay, or diagnostic platform), and a plan that demonstrates how the work could transition toward the clinic or toward broader deployment. The program also explicitly encourages team science and strategic partnerships: applicants who are new to tick-borne disease research are strongly encouraged to collaborate with investigators who have substantial experience in the field, while applicants who already have deep tick-borne disease expertise are strongly encouraged to bring in partners who specialize in therapeutic development, diagnostic assay development, and transition activities, especially collaborators from the commercial sector. This structure reflects an emphasis on both disease-area expertise and the specialized know-how required to move a therapeutic or diagnostic product toward real use.
Administratively, the opportunity is offered by the Department of Defense (Department of the Army, U.S. Army Medical Research Acquisition Activity, USAMRAA) under Funding Opportunity Number HT9425 23 TBDRP TDRA. The funding mechanism allows for either grants or cooperative agreements, indicating that some awards may involve closer government involvement or coordination depending on project needs. The program is listed under CFDA number 12.420 and is categorized as Science and Technology and other Research and Development. Eligibility is described as unrestricted, meaning a wide range of organization types may apply, subject to any additional eligibility clarifications in the full announcement. For FY23, the opportunity anticipated making about four awards. The posting indicates an award ceiling of 0, which usually means applicants should rely on the detailed announcement for any budget constraints or expectations rather than assuming a fixed upper limit from the summary fields. The opportunity was created on April 4, 2023, with an original closing date of August 24, 2023.Apply for HT9425 23 TBDRP TDRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Tick-Borne Disease Research Program Therapeutic/Diagnostic Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Apr 04, 2023.
- Applicants must submit their applications by Aug 24, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD Tick-Borne Disease Research Program (TBDRP) Therapeutic/Diagnostic Research Award (FY23)
What is this funding opportunity?
The DoD Tick-Borne Disease Research Program (TBDRP) Therapeutic/Diagnostic Research Award (FY23) is a competitive Department of Defense grant opportunity intended to advance practical, hypothesis-driven research that can lead to improved treatments and improved diagnostic tools for Lyme disease and other tick-borne diseases.
What is the overall goal of the program?
The program aims to support research with clear translational promise, meaning the work should be positioned to move beyond basic discovery toward real-world clinical impact. A central priority is improving patient care and quality of life for military Service Members, Veterans, their families and beneficiaries, and also the broader U.S. public affected by tick-borne illnesses and related conditions.
What types of projects does this award support?
This award supports two main tracks of work: (1) Treatment-focused projects and (2) Diagnosis-focused projects. Across both tracks, the emphasis is on empirical, product-driven research with measurable development milestones and tangible outputs.
What is the Treatment Focus Area looking for?
Under the Treatment Focus Area, projects are expected to be therapeutic evaluation studies that generate and test new ideas for drug or treatment discovery, particularly at early or preclinical stages. The intent is to build the evidence base needed to move promising therapeutic candidates forward (for example, toward later-stage testing such as large clinical trials).
Does the Treatment Focus Area support early-stage work?
Yes. The Treatment Focus Area is specifically described as supporting therapeutic evaluation studies at early or preclinical stages, with the goal of producing solid, data-driven evidence that can justify advancing candidates to the next development steps.
What is the Diagnosis Focus Area looking for?
Under the Diagnosis Focus Area, proposals should center on diagnostic approaches that can be readily integrated into clinical settings. The emphasis is on diagnostics that are realistic for routine healthcare use, including practical considerations such as usability, fit within clinical workflows, and the steps needed for adoption.
What does "readily integrated into clinical settings" mean for diagnostics?
Based on the opportunity description, it means the diagnostic approach should be designed with real clinical use in mind, not just scientific novelty. This includes attention to usability, workflow fit, and practical adoption considerations in healthcare environments.
Is basic discovery research a good fit for this award?
The opportunity emphasizes translational promise and moving beyond basic discovery. Projects should be positioned to lead toward real-world clinical impact, rather than remaining purely exploratory.
What does the solicitation mean by "empirical and product-driven" research?
It indicates the DoD is looking for data-based projects with tangible development outcomes. Examples of expected features include measurable milestones, concrete outputs (such as a candidate therapeutic strategy, an assay, or a diagnostic platform), and a plan demonstrating how the work could transition toward clinical use or broader deployment.
What kinds of deliverables are implied by this award?
The description suggests deliverables such as a candidate therapeutic strategy, an assay, or a diagnostic platform, supported by empirical results and structured development milestones that show progress toward translation.
Is collaboration encouraged?
Yes. The opportunity explicitly encourages team science and strategic partnerships to combine tick-borne disease expertise with the specialized capabilities needed to advance therapeutics and diagnostics toward real-world use.
What collaboration is recommended for applicants new to tick-borne disease research?
Applicants who are new to tick-borne disease research are strongly encouraged to collaborate with investigators who have substantial experience in the field.
What collaboration is recommended for applicants who already have tick-borne disease expertise?
Applicants who already have deep tick-borne disease expertise are strongly encouraged to bring in partners specializing in therapeutic development, diagnostic assay development, and transition activities, especially collaborators from the commercial sector.
Who is offering this opportunity?
The opportunity is offered by the Department of Defense, specifically the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA).
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is HT9425 23 TBDRP TDRA.
What is the CFDA number for this program?
The opportunity is listed under CFDA number 12.420.
What type of funding instrument is used (grant vs. cooperative agreement)?
The funding mechanism allows for either grants or cooperative agreements. This indicates some awards may involve closer government involvement or coordination depending on project needs.
How many awards were anticipated for FY23?
For FY23, the opportunity anticipated making about four awards.
Is there an award ceiling (maximum budget)?
The posting indicates an award ceiling of 0. In summary listings, that typically means applicants should rely on the detailed announcement for budget constraints or expectations rather than assuming a fixed upper limit from the summary fields.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning a wide range of organization types may apply, subject to any additional eligibility clarifications in the full announcement.
What category is this opportunity listed under?
The opportunity is categorized as Science and Technology and other Research and Development.
When was the opportunity created?
The opportunity was created on April 4, 2023.
What was the original closing date?
The original closing date was August 24, 2023.
What diseases and conditions are within scope?
The award targets Lyme disease and other tick-borne diseases, with a focus on improving treatments and diagnostics for tick-borne illnesses and related conditions.
Who is expected to benefit from the research supported by this award?
A central priority is improving patient care and quality of life for military Service Members, Veterans, their families and beneficiaries, and also the broader U.S. public affected by tick-borne illnesses and related conditions.
What does "translational promise" imply about how projects should be designed?
It implies projects should include a credible plan to move from research results toward practical use, such as clinical impact for patient care or broader deployment of a therapeutic or diagnostic approach.
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