Opportunity Information: Apply for PAR 22 236
Advancing Methods for Safe, Noninvasive, Real Time Assessment of Placenta Development and Function Across Pregnancy (R21 Clinical Trial Not Allowed) is a National Institutes of Health (NIH) grant opportunity that supports early-stage, high-impact research aimed at improving how clinicians and researchers can monitor the human placenta during pregnancy. The central goal is to move the field toward safe, real-time ways to evaluate placental development and function without invasive procedures, or with only minimal invasiveness. In practical terms, the FOA is looking for projects that either advance promising new technologies and measurement approaches or clinically validate emerging methods so they are more reliable, interpretable, and useful across the course of pregnancy. The emphasis on "across pregnancy" highlights the need for tools that can track placental changes over time rather than offering only a one-time snapshot.
This opportunity uses the NIH R21 mechanism, which is commonly intended for exploratory and developmental research. That means it is a good fit for innovative ideas that have strong scientific rationale and preliminary feasibility but still require targeted development, refinement, and proof-of-concept testing. The announcement explicitly states "Clinical Trial Not Allowed," so proposed work must stay on the non-clinical-trial side of human research. In other words, applicants can typically do human-subjects research such as observational studies, method development with human samples or data, and clinical validation that does not meet NIH's definition of a clinical trial, but they cannot propose interventional studies designed to prospectively assign people to an intervention in order to evaluate effects on health-related outcomes.
The funding instrument is a grant, and the activity area is categorized under Health, Income Security and Social Services. The CFDA numbers associated with the opportunity are 93.313 and 93.865, which correspond to NIH programs that commonly support biomedical research and child health and development-related research portfolios. The award ceiling listed is $275,000, indicating the maximum amount available per award under this FOA (applicants should still verify the most current NIH budget rules and any per-year limitations in the full FOA text). While the source data does not specify the exact number of expected awards, it does reflect NIH intent to fund meritorious applications within the available budget.
A wide range of applicant organizations are eligible. Standard eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education); for-profit organizations other than small businesses; small businesses; and other types of organizations that NIH permits. The FOA also explicitly calls out additional eligible groups, underscoring NIH interest in broad participation and diverse institutional perspectives. These include Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Indian/Native American Tribal Governments that are not federally recognized, faith-based or community-based organizations, eligible federal agencies, regional organizations, non-U.S. entities (foreign organizations), and U.S. territories or possessions.
Key administrative details in the provided record include the Funding Opportunity Number PAR-22-236, an original closing date of 2024-11-16, and a creation date of 2022-09-22. Applicants considering this FOA should plan around NIH submission timelines and confirm whether there are multiple receipt dates, any updates or reissues, and the current status of the announcement. Overall, the opportunity is designed to catalyze better, safer ways to evaluate placental health in real time, which can ultimately strengthen pregnancy monitoring and improve understanding of placental biology and dysfunction without relying on invasive testing.Apply for PAR 22 236
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Advancing Methods for Safe, Noninvasive, Real Time Assessment of Placenta Development and Function Across Pregnancy (R21 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.313, 93.865.
- This funding opportunity was created on 2022-09-22.
- Applicants must submit their applications by 2024-11-16. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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